منابع مشابه
Analysis of Meiotic Segregation Patterns and Interchromosomal Effects in Sperm from 13 Robertsonian Translocations
The frequency of the Robertonian (ROB) translocation in newborn babies is approximately one in 1000. Robertsonian translocation is an unusual type of chromosome rearrangement caused by two particular chromosomes joining together. The aim of the study was to analyze the segregation of the ROB translocations in 13 male carriers, and to verify a possible inter-chromosomal effect (ICE) of the ROB t...
متن کاملInterchromosomal Effects of Autosomal Translocations on Recombination in DROSOPHILA MELANOGASTER.
ETEROZYGOUS autosomal translocations have been shown to affect recomHbination in the X chromosome in various ways (HINTON 1965); translocations with long interstitial distances increased recombination in X, those with short interstitial distances decreased recombination in X, and those with intermediate interstitial distances had little or no effect. Other incidental tests of translocation hete...
متن کاملInterchromosomal Effects on Somatic Recombination in Drosophila Melanogaster.
RECOMBINATION in somatic cells of Drosophila is influenced by various genetic and environmental factors that also affect meiotic recombination. Thus, the amount of somatic crossing over in a given chromosome is controlled by the genetic contents of the chromosomal set (WEAVER 1960) and by the presence of various genes (STERN 1936; KAPLAN 1953). It may also be affected by changes in temperature ...
متن کاملSperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18).
BACKGROUND Alanced translocations are associated with infertility, spontaneous abortions and birth defects. METHODS We report the analysis, by multicolour fluorescence in situ hybridization (FISH), of meiotic segregation and aneuploidy of chromosomes X, Y, 7, 8 and 21 in sperm from three men who are carriers of two different translocations involving chromosomes 11 and 18. A control group comp...
متن کاملInterchromosomal association and gene regulation in trans.
The nucleus is an ordered three-dimensional entity, and organization of the genome within the nuclear space might have implications for orchestrating gene expression. Recent technological developments have revealed that chromatin is folded into loops bringing distal regulatory elements into intimate contact with the genes that they regulate. Such intrachromosomal contacts appear to be a general...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1955
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.41.11.911